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| Registros recuperados: 18.180 | |
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| Galbiatti,A.L.S.; Ruiz,M.T.; Biselli-Chicote,P.M.; Raposo,L.S.; Maniglia,J.V.; Pavarino-Bertelli,E.C.; Goloni-Bertollo,E.M.. |
| The functional effect of the A>G transition at position 2756 on the MTR gene (5-methyltetrahydrofolate-homocysteine methyltransferase), involved in folate metabolism, may be a risk factor for head and neck squamous cell carcinoma (HNSCC). The frequency of MTR A2756G (rs1805087) polymorphism was compared between HNSCC patients and individuals without history of neoplasias. The association of this polymorphism with clinical histopathological parameters was evaluated. A total of 705 individuals were included in the study. The polymerase chain reaction-restriction fragment length polymorphism technique was used to genotype the polymorphism. For statistical analysis, the chi-square test (univariate analysis) was used for comparisons between groups and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Head and neck cancer; Polymorphism; Folate metabolism; MTR gene. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000500005 |
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| Sá,Matheus Malta de; Pasqualoto,Kerly Fernanda Mesquita; Rangel-Yagui,Carlota de Oliveira. |
| Drugs acting on the central nervous system (CNS) have to cross the blood-brain barrier (BBB) in order to perform their pharmacological actions. Passive BBB diffusion can be partially expressed by the blood/brain partition coefficient (logBB). As the experimental evaluation of logBB is time and cost consuming, theoretical methods such as quantitative structure-property relationships (QSPR) can be useful to predict logBB values. In this study, a 2D-QSPR approach was applied to a set of 28 drugs acting on the CNS, using the logBB property as biological data. The best QSPR model [n = 21, r = 0.94 (r² = 0.88), s = 0.28, and Q² = 0.82] presented three molecular descriptors: calculated n-octanol/water partition coefficient (ClogP), polar surface area (PSA), and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Two-dimensional quantitative structure-property relationships (2D-QSPR); Calculated n-octanol/water partition coefficient (ClogP); Blood-brain barrier; Benzodiazepines. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000400016 |
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| Huret, Martin; Petitgas, Pierre; Struski, Caroline; Leger, Fabien; Sourisseau, Marc; Lazure, Pascal. |
| Overexploitation and climate change are increasingly causing unanticipated changes in marine ecosystems, such as higher variability in fish recruitment and shifts in species distribution, pressing for developing fisheries oceanography. In the meantime, operational oceanography rapidly progresses and its products become easy to access to a large community, among them fisheries scientists. Multiyear oceanographic reanalyses (hindcasts) were identified has a priority product by the ICES WG on Operational Oceanographic Products for Fisheries and Environment (WGOOFE). We performed a 37 years hindcast (1972-2008) run with a coupled physical-biogeochemical model (ECO-MARS3D) over the Bay of Biscay, using realistic meteorological and run-off forcing. We first... |
| Tipo: Text |
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| Ano: 2010 |
URL: http://archimer.ifremer.fr/doc/00023/13432/10442.pdf |
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| GASQUES, J. G.; VIEIRA FILHO, J. E. R.; NAVARRO, Z.. |
| Primeira parte: Desempenho produtivo e estrutura. Cap. 1 - Produtividade total dos fatores e transformações da agricultura brasileira: análise dos dados dos censos agropecuários; Cap. 2 - Evolução recente da estrutura fundiária e propriedade rural no Brasil. Segunda parte: Mudança tecnológica e especificidades setoriais. Cap. 3 Trajetória tecnológica e aprendizado no setor agropecuário; Cap. 4 - Inovação tecnológica na agricultura, o papel da biotecnologia agrícola e a emergência de mercados regulados; Cap. 5 - Mudanças e reiteração da heterogeneidade do mercado de trabalho agrícola. terceira parte: Segmentações sociais e disputas sociopolíticas. Cap. 6 - Os desafios das agriculturas brasileiras; Cap. 7 - A agricultura familiar no Brasil: entre a política... |
| Tipo: Livro técnico (INFOTECA-E) |
Palavras-chave: Produtividade agrícola; Desenvolvimento rural. |
| Ano: 2010 |
URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/904332 |
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| Carmo,Renato Miguel do. |
| Em Portugal, as ciências sociais têm estudado a agricultura familiar a partir de um modelo de interpretação dualista que acentua as diferenças inter-regionais, marginalizando, até certo ponto, o significado sociológico de algumas continuidades que se estabeleciam (e se estabelecem) entre as zonas do Norte e do Sul ou entre o Litoral e o Interior. O presente estudo pretende, assim, construir uma perspectiva diferente sobre as modalidades de agricultura familiar em Portugal, procurando identificar, num primeiro momento, uma série de proximidades sociológicas entre os diferentes modos de organização (tradicionais e modernos) das famílias agrícolas e, consequentemente, traçar os eixos para um modelo mais complexo na análise dessas mesmas modalidades. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Rural; Pluriactividade; Agricultura familiar; Portugal. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-20032010000100001 |
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| Silva,M.L.; Martins,B.C.; Ribeiro,A.P.; Souza,A.L. Groszewicz de; Laus,J.L.. |
| A- and B-modes ultrasonographic changes in the thickness of various structures of the eyeball in male and female English Cocker Spaniel dogs with and without nondiabetic cataracts were evaluated. Sixteen dogs with cataracts (32 eyes) and seven normal dogs (14 eyes) older than eight years were selected. A- and B-modes ultrasonography was performed with a 10MHz transducer. Data was statistically evaluated by one way ANOVA. Mean and standard deviations of various ocular structures for dogs with and without cataracts were, respectively, anterior chamber: 3.041±0.828mm, 3.373±1.040mm; lens: 6.817±1.117mm, 7.062±0.477mm; vitreous: 10.056±0.754mm, 9.523±0.705mm; and axial length: 19.909±1.103mm, 19.958±1.050mm. Ocular measurements between right and left eyes,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dog; Ultrasonography; Cataract. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000500009 |
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| Registros recuperados: 18.180 | |
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